dinsdag 2 december 2014

men geeft ons toch altijd een sprankeltje hoop

the Brain research foundation publiceerde volgend bericht op hun site :




HNPP
A Study of Provocation and Treatment of HNPP
2008 Seed Grant
Raymond P. Roos, M.D.
University of Chicago

Charcot-Marie Tooth (CMT) comprises a group of inherited peripheral neuropathies. One form of CMT called hereditary liability to pressure palsies (HNPP) is manifest by recurrent episodes of traumatic or compressive peripheral neuropathies.  HNPP is caused by a deletion of a myelin gene called PMP-22.  It is known that vitamin C decreases the expression of PMP-22 and progesterone increases its expression.  The thrust of this application is to investigate whether vitamin C ingestion can influence (and worsen) HNPP clinical disease and whether progesterone can be used as a treatment of HNPP.  The study will test the effect of vitamin C and progesterone treatment on the clinical and pathological disease of an HNPP mouse.

There is presently no treatment of any form of CMT.  The findings of this proposal may have important implications regarding our understanding and treatment of HNPP.  As a result of this study, HNPP patients may be cautioned about excess vitamin C ingestion. In addition, the findings of the present study could lead to a clinical trial with progesterone in HNPP patients.
- See more at: http://www.thebrf.org/Research+Topics/HNPP#sthash.PVVpsBDK.dpuf

HNPP

A Study of Provocation and Treatment of HNPP
2008 Seed Grant
Raymond P. Roos, M.D.
University of Chicago

Charcot-Marie Tooth (CMT) comprises a group of inherited peripheral neuropathies. One form of CMT called hereditary liability to pressure palsies (HNPP) is manifest by recurrent episodes of traumatic or compressive peripheral neuropathies.  HNPP is caused by a deletion of a myelin gene called PMP-22.  It is known that vitamin C decreases the expression of PMP-22 and progesterone increases its expression.  The thrust of this application is to investigate whether vitamin C ingestion can influence (and worsen) HNPP clinical disease and whether progesterone can be used as a treatment of HNPP.  The study will test the effect of vitamin C and progesterone treatment on the clinical and pathological disease of an HNPP mouse.

There is presently no treatment of any form of CMT.  The findings of this proposal may have important implications regarding our understanding and treatment of HNPP.  As a result of this study, HNPP patients may be cautioned about excess vitamin C ingestion. In addition, the findings of the present study could lead to a clinical trial with progesterone in HNPP patients.
- See more at: http://www.thebrf.org/Research+Topics/HNPP#sthash.PVVpsBDK.dpuf

HNPP

A Study of Provocation and Treatment of HNPP
2008 Seed Grant
Raymond P. Roos, M.D.
University of Chicago

Charcot-Marie Tooth (CMT) comprises a group of inherited peripheral neuropathies. One form of CMT called hereditary liability to pressure palsies (HNPP) is manifest by recurrent episodes of traumatic or compressive peripheral neuropathies.  HNPP is caused by a deletion of a myelin gene called PMP-22.  It is known that vitamin C decreases the expression of PMP-22 and progesterone increases its expression.  The thrust of this application is to investigate whether vitamin C ingestion can influence (and worsen) HNPP clinical disease and whether progesterone can be used as a treatment of HNPP.  The study will test the effect of vitamin C and progesterone treatment on the clinical and pathological disease of an HNPP mouse.

There is presently no treatment of any form of CMT.  The findings of this proposal may have important implications regarding our understanding and treatment of HNPP.  As a result of this study, HNPP patients may be cautioned about excess vitamin C ingestion. In addition, the findings of the present study could lead to a clinical trial with progesterone in HNPP patients.
- See more at: http://www.thebrf.org/Research+Topics/HNPP#sthash.PVVpsBDK.dpuf

HNPP

A Study of Provocation and Treatment of HNPP
2008 Seed Grant
Raymond P. Roos, M.D.
University of Chicago

Charcot-Marie Tooth (CMT) comprises a group of inherited peripheral neuropathies. One form of CMT called hereditary liability to pressure palsies (HNPP) is manifest by recurrent episodes of traumatic or compressive peripheral neuropathies.  HNPP is caused by a deletion of a myelin gene called PMP-22.  It is known that vitamin C decreases the expression of PMP-22 and progesterone increases its expression.  The thrust of this application is to investigate whether vitamin C ingestion can influence (and worsen) HNPP clinical disease and whether progesterone can be used as a treatment of HNPP.  The study will test the effect of vitamin C and progesterone treatment on the clinical and pathological disease of an HNPP mouse.

There is presently no treatment of any form of CMT.  The findings of this proposal may have important implications regarding our understanding and treatment of HNPP.  As a result of this study, HNPP patients may be cautioned about excess vitamin C ingestion. In addition, the findings of the present study could lead to a clinical trial with progesterone in HNPP patients.
- See more at: http://www.thebrf.org/Research+Topics/HNPP#sthash.PVVpsBDK.dpuf

HNPP

A Study of Provocation and Treatment of HNPP
2008 Seed Grant
Raymond P. Roos, M.D.
University of Chicago

Charcot-Marie Tooth (CMT) comprises a group of inherited peripheral neuropathies. One form of CMT called hereditary liability to pressure palsies (HNPP) is manifest by recurrent episodes of traumatic or compressive peripheral neuropathies.  HNPP is caused by a deletion of a myelin gene called PMP-22.  It is known that vitamin C decreases the expression of PMP-22 and progesterone increases its expression.  The thrust of this application is to investigate whether vitamin C ingestion can influence (and worsen) HNPP clinical disease and whether progesterone can be used as a treatment of HNPP.  The study will test the effect of vitamin C and progesterone treatment on the clinical and pathological disease of an HNPP mouse.

There is presently no treatment of any form of CMT.  The findings of this proposal may have important implications regarding our understanding and treatment of HNPP.  As a result of this study, HNPP patients may be cautioned about excess vitamin C ingestion. In addition, the findings of the present study could lead to a clinical trial with progesterone in HNPP patients.
- See more at: http://www.thebrf.org/Research+Topics/HNPP#sthash.FgsRs24h.dpuf

HNPP

A Study of Provocation and Treatment of HNPP
2008 Seed Grant
Raymond P. Roos, M.D.
University of Chicago

Charcot-Marie Tooth (CMT) comprises a group of inherited peripheral neuropathies. One form of CMT called hereditary liability to pressure palsies (HNPP) is manifest by recurrent episodes of traumatic or compressive peripheral neuropathies.  HNPP is caused by a deletion of a myelin gene called PMP-22.  It is known that vitamin C decreases the expression of PMP-22 and progesterone increases its expression.  The thrust of this application is to investigate whether vitamin C ingestion can influence (and worsen) HNPP clinical disease and whether progesterone can be used as a treatment of HNPP.  The study will test the effect of vitamin C and progesterone treatment on the clinical and pathological disease of an HNPP mouse.

There is presently no treatment of any form of CMT.  The findings of this proposal may have important implications regarding our understanding and treatment of HNPP.  As a result of this study, HNPP patients may be cautioned about excess vitamin C ingestion. In addition, the findings of the present study could lead to a clinical trial with progesterone in HNPP patients.
- See more at: http://www.thebrf.org/Research+Topics/HNPP#sthash.FgsRs24h.dpuf

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